Povidone iodine


Thông tin thuốc gốc
Chỉ định và Liều dùng
Mouth/Throat
Mouth and throat infections, Oral hygiene
Adult: As 1% solution: Rinse or gargle 10 mL undiluted solution with an equal volume of warm water for 30 seconds 4 times daily for up to 14 days, or as directed.
Child: As 1% solution: >6 years Same as adult dose.

Ophthalmic
Prophylaxis of ocular infection following surgical procedures
Adult: As 5% solution: Instill 2-3 drops  onto affected eye(s), leave for 2 minutes then rinse off with 0.9% Na chloride solution.

Topical/Cutaneous
Acne vulgaris
Adult: As 4% solution: Apply bid directly or with moistened sponge unto affected area, leave for 3-5 minutes then rinse off with water.
Child: As 4% solution: >2 years Same as adult dose.

Topical/Cutaneous
Pyoderma, Seborrhoeic dermatitis
Adult: As 4% shampoo: Apply 2-3 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved.
Child: As 4% shampoo: 2-12 years Apply 1-2 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved. >12 years Same as adult dose.

Topical/Cutaneous
Antiseptic
Adult: As 5-10% solution, 10% gel, 10% ointment, or 10 % aerosol spray: Apply as directed.
Child: As 5-10% solution, 10% gel or 10% ointment: Same as adult dose. As 10% aerosol spray: ≥2 years Same as adult dose.

Vaginal
Vaginal irritation
Adult: As 0.3% douche: Insert 0.3% solution once daily for 5-7 days.
Tương kỵ
May cause bubbly brown explosion with hydrogen peroxide solution.
Chống chỉ định
History of abnormal thyroid function or goitre (e.g. nodular colloid goitre, endemic goitre, Hashimoto’s thyroiditis).
Thận trọng
Patient with serious wounds including burns. Renal impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Hypo- or hyper-thyroidism (long-term). Rarely, hypersensitivity reactions; conjunctival hyperaemia, superficial punctuate keratitis, cytotoxicity (ophth).
Dermatologic: Rarely, local irritation, pruritus, rash, oedema, burns.
Topical/Vag: D; Ophth: C
Tương tác
May increase risk of thyroid-related reactions with lithium. Risk of formation of caustic compounds with ophthalmic formulations containing Hg-based preservatives.
Ảnh hưởng đến kết quả xét nghiệm
May interfere with thyroid function tests. False-positive result with contaminated povidone iodine for the detection of occult blood in stool or blood in urine.
Tác dụng
Description:
Mechanism of Action: Povidone iodine is an iodophore that has a broad-spectrum germicidal activity against a wide range of bacteria, viruses, fungi, protozoa and spores. It is a complex of polyvinylpyrrolidone (povidone) with iodine. After application, it gradually and continuously delivers iodine to exert its germicidal activity.
Pharmacokinetics:
Absorption: Absorbed from skin, vaginal mucosa.
Distribution: Crosses the placenta and enters breast milk.
Excretion: Mainly via urine.
Bảo quản
Store below 25°C. Protect from light.
Phân loại MIMS
Thuốc trị mụn / Các thuốc nhãn khoa khác / Thuốc dùng trong viêm & loét miệng / Thuốc tác dụng lên âm đạo / Thuốc trị vẩy nến, tăng tiết bã nhờn & vảy cá / Thuốc khử trùng & sát trùng da
Phân loại ATC
D09AA09 - povidone-iodine ; Belongs to the class of ointment dressings with antiinfectives.
D11AC06 - povidone-iodine ; Belongs to the class of medicated shampoos.
D08AG02 - povidone-iodine ; Belongs to the class of iodine product antiseptics. Used in the treatment of dermatological diseases.
S01AX18 - povidone-iodine ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections.
G01 - GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ; Used in the treatment of gynecological infections.
R02AA15 - povidone-iodine ; Belongs to the class of antiseptics used in throat preparations.
Tài liệu tham khảo
Anon. Povidone-Iodine (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/01/2018.

Anon. Povidone-Iodine (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/01/2018.

Aplicare Povidone-Iodine Gel (Aplicare, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Betadine Gargle and Mouthwash (Ayrton Saunders Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 16/01/2018.

Betadine Shampoo (Ayrton Saunders Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 16/01/2018.

Betadine Skin Cleanser (Ayrton Saunders Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 16/01/2018.

Betadine Solution (Alcon Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Betadine Solution (Purdue Products LP). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Betadine Spray (Purdue Products LP). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Betadine Surgical Scrub Solution (Purdue Products LP). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Betadine Swab (Purdue Products LP). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Buckingham R (ed). Povidone-Iodine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/01/2018.

Joint Formulary Committee. Povidone-Iodine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/01/2018.

Major Povidone-Iodine Ointment (Major Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

Recuro Vaginal Douche (Iona Pharmacy). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/01/2018.

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